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Welcome to the Cardiogenetics Lab

Our group studies the underlying genetic and molecular mechanisms of electrocardiographic structure and function, cardiac hypertrophy, systemic inflammation; and risk factors for sudden cardiac death/drug toxicity. We are applying our discoveries to identify individuals susceptible to rare cardiac arrhythmias, cardiomyopathies, and drug-induced cardiotoxicity, to improve cardiac risk profiles for populations, and to identify novel genes and pathways that can enable targeted prevention and treatment and potentially result in new diagnostic tests and therapies. We are also interested in muscular dystrophies as often they are associated with cardiac complications including cardiomyopathy.

Individual projects focus on: 
  1. The association between DNA variants, both common and rare, in twin and general population studies with various cardiovascular traits, particular cardiac arrhythmias and cardiomyopathies
  2. Next generation sequencing to identify causal mutations in inherited cardiac arrhythmias such as Long QT and Brugada syndrome, and cardiomyopathies such as Hypertrophic cardiomyopathy and Dilated Cardiomyopathy - conditions associated with a high risk of sudden cardiac death,
  3. Next generation sequencing to identify causal mutations in inherited muscular dystrophies, particularly those associated with cardiomyopathy,
  4. Understanding the functional consequences of rare and common variants identified using morpholino knockdown/CRISPR technology in zebrafish, cell culture models, and gene expression studies.

We welcome collaborations with patients, clinicians, and scientists, and we are actively seeking patients and families with inherited cardiovascular disorders who may be interested in participating in this research.

You can contact us by email:   cardiogeneticslab@sgul.ac.uk

 

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